Penn Researchers Identify New Treatment Target for Melanoma

Researchers in the Perelman School of Medicine at the University of Pennsylvania have identified a new therapeutic target for the treatment of melanoma. For decades, research has associated female sex and a history of previous pregnancy with better outcomes after a melanoma diagnosis. Now, a research team from Perelman School of Medicine at the University of Pennsylvania says it may have determined the reason for the melanoma-protective effect. The mechanism is related to a cellular protein called the G protein-coupled estrogen receptor (GPER). When GPER was activated and combined with anti PD-1inhibitor drugs in mouse cancer models, the therapy dramatically extended survival in all animals and completely eliminated the tumor in 50 percent of the mice. Researchers published their findings in the journal eLife today.

LIA Diagnostics, ImmERge Labs join Science Center health accelerator

It’s been quite a year for scientist Marion Leary.

First, her startup ImmERge Labs spun out from Penn, kicking things off by landing the $50,000 first prize at the AppItUP Demo Day. Then, she scores Geek of the Year at the Philly Geek Awards. And now, her company was announced as one of seven tech startups joining the University City Science Center’s Digital Health Accelerator.

Virtual Reality Can Save Your Life

The woman on the treadmill next to you at the gym collapses. You rush to her side, but she’s not breathing and has no pulse. Do you know what to do next?

If not, virtual reality may be the key to saving her life.

Unlike a heart attack, which occurs when blood flow to the heart is blocked, sudden cardiac arrest (SCA) is triggered by electrical malfunction. It comes on suddenly and often without warning.

The heart stops beating. Blood can’t reach the brain, lungs, and other vital organs. The victim loses consciousness and, without treatment, will die within minutes.

ImmERge Labs’ new CPR Virtual Teachable Moment At American Crane & Equipment Corporation

American Crane recently had the opportunity to open their facility to the ImmERge Labs, an Upstart company spun out of the University of Pennsylvania, to introduce their employees to some of the newest and most innovative technology being applied in the medical field today.

After recently completing their official CPR certification training, American Crane’s employees had the chance to experience what would happen in a real life situation where they had to perform CPR through ImmERge Labs’ new CPR Virtual Teachable Moment℠ program.

Cancer Survivor Becomes a Cancer Fighter at a Philly Start-Up

What Debra Travers really wanted to be was a marine biologist, until “I found out Jacques Cousteau wasn’t hiring.”

How she wound up as chief executive of PolyAurum LLC, a Philadelphia start-up developing biodegradable gold nanoparticles for treating cancerous tumors, involved a professional journey of more than 30 years in pharmaceutical and diagnostics industries, and a personal battle with the disease she’s now in business to defeat.

CARMA Therapeutics Closes Initial Funding to Advance Chimeric Antigen Receptor Macrophages (CARMA) to Treat Solid Tumors

CARMA Therapeutics Inc., a biotechnology company developing cellular immunotherapies, co-founded by the University of Pennsylvania (Penn), announced today that it has closed an initial financing. The financing was co-led by AbbVie Ventures and HealthCap with participation by Grazia Equity and IP Group Inc. CARMA Therapeutics is building a pipeline of cancer programs using its proprietary CARMA platform, combining chimeric antigen receptor targeting with macrophages to tackle solid tumors. The proceeds will be used primarily to advance the development of its first product, CARMA-0508, an adoptive cellular immunotherapy using chimeric antigen receptor macrophages (CARMA) for the treatment of metastatic solid tumors. Specific terms of the financing transaction were not disclosed.

Rising Penn star Saar Gill gets funding for a next-gen CAR-T startup, adding a new weapon to the mix

Earlier this month, the University of Pennsylvania’s Saar Gill turned up at ASCO to present new data demonstrating that a combination of Imbruvica with Novartis’ next-gen CAR-T CTL119 proved very effective in treating particularly lethal cases of chronic lymphocytic leukemia, wiping out all signs of the disease in 8 of 9 treatment-resistant patients enrolled in an exploratory study.

Power Moves: A Penn spinout that wants to save lives through VR just hired a CEO

Are you prepared to save someone’s life if they suddenly collapse next to you on the street? ImmERge Labs already knows most people aren’t. Founded by University of Pennsylvania researcher Marion Leary — who heads up innovation research at Penn’s Center for Resuscitation Science, the startup is now out of stealth mode and hired Matt Grabowsky as its CEO.

Ostiio wants to improve quality of life for kids with craniofacial defects

Ostiio is a Philadelphia medical device startup that’s just a few months old but has big ambitions: improving the quality of life for children with craniofacial defects, such as craniosynostosis and defects in the midface or lower jaw. The company was part of an entourage of technology entrepreneurs from Philadelphia through the Penn Center for Innovation and Amplify Philly at the SXSW conference in Austin this week. Craniosynostosis is a condition in which one or more of the joints between an infant’s skull prematurely fuse before the brain is fully formed. The condition results in a misshapen head because the brain continues to grow, according to the Mayo Clinic’s website. It affects one in every 2,000 to 3,000 infants.